Institute for Genome Sciences
International Livestock Research Institute
Current News
February 2015
Malaria parasites unlikely to jump from animals to humans
A new study indicates that it is unlikely that Plasmodium species that infect other animals would cross over easily to humans.. read more
December 2014
Scientists Find Multiple Wolbachia Genomes Integrated in a Drosophila Chromosome
Investigators found multiple complete bacterial genomes integrated into an animal genome
Publications
Cis regulatory motifs and antisense transcriptional control in the apicomplexan Theileria parva.
Tretina K, R Pelle and JC Silva.
BMC Genomics. 2016 17(1):128. [read more].
Quantification of the ratio of host-to-parasite DNA in samples from Theileria parva-infected host lymphocyte cell lines.
Gotia HT, JB Munro, DP Knowles, CA Daubenberger, RP Bishop, JC Silva.
PLoS One. 2016 11(3):e0150401. [read more].
The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence.
Norling M, Bishop RP, Pelle R, Qi W, Henson S, Drábek EF, Tretina K, Odongo D, Mwaura S, Njoroge T, Bongcam-Rudloff E, Daubenberger CA, Silva JC.
BMC Genomics. 2015 Sep 24 [read more].
Publications
Cis regulatory motifs and antisense transcriptional control in the apicomplexan Theileria parva.
Tretina K, R Pelle and JC Silva.
BMC Genomics. 2016 17(1):128. PMID: 26896950.
Quantification of the ratio of host-to-parasite DNA in samples from Theileria parva-infected host lymphocyte cell lines.
Gotia HT, JB Munro, DP Knowles, CA Daubenberger, RP Bishop, JC Silva.
PLoS One. 2016 11(3):e0150401. PMID: 26930209.
The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence.
Norling M, Bishop RP, Pelle R, Qi W, Henson S, Drábek EF, Tretina K, Odongo D, Mwaura S, Njoroge T, Bongcam-Rudloff E, Daubenberger CA, Silva JC.
BMC Genomics. 2015 Sep 24;16(1):729. doi: 10.1186/s12864-015-1910-9. PMID: 26403690.
Theileria-transformed bovine leukocytes have cancer hallmarks.
Tretina K, Gotia HT, Mann DJ, Silva JC.
Trends Parasitol. 2015 May 4. pii: S1471-4922(15)00077-X. doi:
10.1016/j.pt . [Epub ahead of print] Review. PMID: 25951781
Molecular evolution of a central region containing B cell epitopes in the gene encoding the p67 sporozoite antigen within a field population of Theileria parva.
Obara I, Ulrike S, Musoke T, Spooner PR, Jabbar A, Odongo D, Kemp S, Silva JC, Bishop RP.
Parasitol Res. 2015 Feb 13. [Epub ahead of print] PubMed PMID: 25673078
Comparative genomic analysis and phylogenetic position of Theileria equi.
Kappmeyer LS, Thiagarajan M, Herndon DR, Ramsay JD, Caler E, Djikeng A, Gillespie JJ, Lau AO, Roalson EH, Silva JC, Silva MG, Suarez CE, Ueti MW, Nene VM, Mealey RH, Knowles DP, Brayton KA.
BMC Genomics. 2012 Nov 9. PubMed PMID: 23137308
The origin of the 'Mycoplasma mycoides cluster' coincides with domestication of ruminants.
Fischer A, Shapiro B, Muriuki C, Heller M, Schnee C, Bongcam-Rudloff E, Vilei EM, Frey J, Jores J.
Plos One. 2012. Epub 2012 Apr 27. PubMed PMID: 22558362
Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity.
Pelle R, Graham SP, Njahira MN, Osaso J, Saya RM, Odongo DO, Toye PG, Spooner PR, Musoke AJ, Mwangi DM, Taracha EL, Morrison WI, Weir W, Silva JC, Bishop RP.
PLoS One. 2011 Apr 29. PubMed PMID: 21559495
Properties of non-coding DNA and identification of putative cis-regulatory elements in Theileria parva.
Guo X, Silva JC.
BMC Genomics. 2008 Dec 3. PubMed PMID: 19055776
Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes.
Gardner MJ, Bishop R, Shah T, de Villiers EP, Carlton JM, Hall N, Ren Q, Paulsen IT, Pain A, Berriman M, Wilson RJ, Sato S, Ralph SA, Mann DJ, Xiong Z, Shallom SJ, Weidman J, Jiang L, Lynn J, Weaver B, Shoaibi A, Domingo AR, Wasawo D, Crabtree J, Wortman JR, Haas B, Angiuoli SV, Creasy TH, Lu C, Suh B, Silva JC, Utterback TR, Feldblyum TV, Pertea M, Allen J, Nierman WC, Taracha EL, Salzberg SL, White OR, Fitzhugh HA, Morzaria S, Venter JC, Fraser CM, Nene V.
Science. 2005 July 1. PubMed PMID: 159945588
