Institute for Genome Sciences
International Livestock Research Institute
Malaria parasites unlikely to jump from animals to humans
A new study indicates that it is unlikely that Plasmodium species that infect other animals would cross over easily to humans.. read more
Scientists Find Multiple Wolbachia Genomes Integrated in a Drosophila Chromosome
Investigators found multiple complete bacterial genomes integrated into an animal genome
Cis regulatory motifs and antisense transcriptional control in the apicomplexan Theileria parva.
Tretina K, R Pelle and JC Silva.
BMC Genomics. 2016 17(1):128. [read more].
Quantification of the ratio of host-to-parasite DNA in samples from Theileria parva-infected host lymphocyte cell lines.
Gotia HT, JB Munro, DP Knowles, CA Daubenberger, RP Bishop, JC Silva.
PLoS One. 2016 11(3):e0150401. [read more].
The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence.
Norling M, Bishop RP, Pelle R, Qi W, Henson S, Drábek EF, Tretina K, Odongo D, Mwaura S, Njoroge T, Bongcam-Rudloff E, Daubenberger CA, Silva JC.
BMC Genomics. 2015 Sep 24 [read more].
The Mycoplasma mycoides cluster
Dr. Joerg Jores described, in a recent study by researchers from ILRI, the International Centre of Insect Physiology and Ecology and partners in Germany, Sweden, Switzerland and the USA, the history and relationships of pathogens that cause both bovine and caprine diseases such as contagious bovine pleuropneumonia and contagious caprine pleuropneumonia.
The study, 'The origin of the "Mycoplasma mycoides cluster" coincides with domestication of ruminants,' was published in the April 2012 edition of the Public Library of Science (PLoS, 27 Apr 2012). The researchers found that the members of the so called 'Mycoplasma mycoides cluster', which cause contagious bovine pleuropneumonia and other diseases in ruminants, arose at the same time as humans first started to domesticate wild ruminants.
The onset of domestication of livestock about 10,000 years ago, which established large ruminant populations and the herding of mixed species, is thought to have contributed to creating the conditions favoring the spread and diversification of the pathogens by allowing them to adapt to different hosts.
We are now exploiting large-scale comparative genomics, pan-genome and reverse vaccinology approaches to study the 'Mycoplasma mycoides cluster' in order to develop diagnostic assays and vaccines for the benefit of the livestock dependent people.